The product occurs as a tautomeric mixture, the keto and enol forms being in equilibrium.
Appearance White crystalline powder
Odour Practically odourless
Allantoin, known for many years for its therapeutic action on skin tissue,1 is widespread in animal organisms and in plant material. Allantoin has been used for centuries in the folk medicine of many countries, to promote wound healing. In 1912, Macalister2 demonstrated that the active substance of black salsify is identical with Allantoin, and in 1935 Robinson was successful in isolating Allantoin from animal organisms as the principal active ingredient. Before its isolation from natural products, Allantoin was successfully synthesized for the first time in 1838 by Woehler and Liebig. Following Robinson’s initial publications, the results of his studies were quickly applied in the medical and pharmaceutical sectors. A number of Allantoin-containing wound ointments and healing ointments were newly introduced in surgery and dermatology, and existing products of this type were improved by addition of Allantoin. Allantoin became established in the cosmetic industry many years ago, so it is already present in many cosmetic products. Particularly in this area, consumption has grown steadily.
Addition of Allantoin to wound ointments and healing compositions promotes wound cleansing and healing. The indications for formulations of this kind are many, ranging from small, everyday injuries (cuts, burns, abrasions, chapped skin), to wounds that are slow to heal or purulent, refractory ulcers of various origins, to treatment of burns of various degrees and origins (thermal or radiation). Fisher5 showed in several studies that a preparation of 5% Allantoin in VaselineÂ® gave benefit in the treatment of leg ulcers, psoriasis and dry skin. Formulations containing Allantoin also have beneficial effects on eczema, contact dermatitis of the hands, hyperkeratosis, periodontosis and heat blisters in the mouth and on mucous membranes. What is especially advantageous is that the wounds heal without keloid formation. Internal and external haemorrhoids will respond well to suppositories and ointments containing Allantoin. Suitable vehicles for Allantoin include washable ointments of the oil-in-wateremulsion type. It is advisable to incorporate Allantoin in the aqueous phase of the formulation.