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Aako BV
P.O. Box 205
3830 AE Leusden
The Netherlands
KvK 31009627

Coenzym Q-10

Therapeutic use
Excipient

General description

CAS: 303-98-0

The group of ubiquinones can be found nearly everywhere in the living nature. The length of the side chain may vary according to different species. In humans an ubiquinone with the side chain length of 10 units is found predominantly, which is also called Coenzyme Q10.
Coenzyme Q10 is a vitamin-like substance. Its structure is similar to vitamin E and vitamin K, but it has different and unique functions. In every cell Coenzyme Q10 is an essential mitochondrial component where it plays a key role in the respiratory chain. From Coenzyme Q10 electrons flow over cytochromes to molecular oxygen. With the electron transport system of this chain the human
body generates the energy necessary for life. Thus, the highest levels are found in organs with highrates of metabolism like the liver, the heart, and the kidney.
The healthy human organism can synthesize sufficient amounts of coenzyme Q10, however, under certain conditions and with various diseases Q10 deficiencies have been described. Therefore it is used as a pharmaceutical substance in cardiology for various heart diseases.
Furthermore, Coenzyme Q10 acts as a potent antioxidant in the lipid phase of cells. Coenzyme Q10 itself has a lipophilic character and thus is concentrated in the sub cellular structures.
 

Applications

Our skin is attacked by various oxidative stresses from outside such as UV radiation and from inside by molecules generated during cell metabolism. To cope with them the body disposes of different enzymatic and non-enzymatic
(antioxidant) mechanisms.
Coenzyme Q 10 is an important antioxidant acting in the lipid parts of the cells together with vitamin E and vitamin C. The coenzyme Q10 levels of the epidermis is ten times higher than in the dermis. It declines with aging, calculated with reference to cholesterol. Modern cosmetics aim to reduce the
signs of ageing in the skin, where oxidative stress is thought to play a major role. Apart from normal, chronological aging which is thought to create shallow small wrinkles especially the signs of photoaging, such as deep wrinkles are targeted by cosmetic formulators.
By virtue of its unique functions Coenzyme Q 10 is an attractive active ingredient for such cosmetic formulations. It penetrates into living cell layers of the epidermis. In porcine skin 20% penetrated to the epidermis and 2% to the dermis. In the dermis it is reduced from ubiquinone to ubiquinol, the active antioxidant.
 

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Aako BV
P.O. Box 205
3830 AE Leusden
The Netherlands
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