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Aako BV
P.O. Box 205
3830 AE Leusden
The Netherlands
KvK 31009627

Protectol DA

CAS number:
1777-82-8
INCI:
2,4-Dichlorobenzyl Alcohol
EINECS number:
217-210-5
Functionality
Preservative / Biocide
Non Governmental organization
-

General description

Protectol DA preservative (2,4-Dichlorobenzyl alcohol) is a well recognised, safe and reliable,broad spectrum antifungal preservative for use in a range of products including cosmetic, suncare, toiletry and baby care products. Protectol DA is also an effective antimicrobial active ingredient for use in oral and topical pharmaceuticals.

QUALITY

Protectol DA is a white to slightly yellow crystalline solid of minimum 98% purity with a shelf life of at least 3 years. The INCI name is 2,4-Dichlorobenzyl alcohol. Protectol DA is a special grade currently available for use in pharmaceuticals and other specialist applications requiring access to a Drug Master File.

ANTIMICROBIAL ACTIVITY

Protectol DA is active against a broad range of microorganisms, but is more effective against fungi. Minimum Inhibitory Concentrations (M.I.C.) of Protectol DA against four key organisms are as follows: In formulations where broad spectrum control is required, Protectol DA can be used in combination with other antimicrobials with well known bactericidal activity.

USAGE RECOMMENDATIONS

Protectol DA is highly soluble in organic solvents and sparingly soluble in water. In emulsion systems, it can be incorporated by dissolution into the oil phase. In aqueous systems, the use of an organic solvent carrier is helpful. For example, a 20% w/v solution of Protectol DA can be prepared in propylene glycol to facilitate addition. Protectol DA is extremely stable at high temperature and over a wide pH range and can offer effective control for products formulated at high pH. Protectol DA is compatible with all commonly used surfactant types - anionic, cationic, nonionic and amphoteric. It is also compatible with other antimicrobials such as Bronopol (Myacide Pharma BP).

RECOMMENDED DOSE RATES

Effective preservation can be achieved in a variety of formulations where fungal contamination is a problem. From cosmetics and toiletries to suncare  and babycare products, Protectol DA may be of particular value to formulators looking for a safe and effective antifungal agent. The majority of consumer product types can be preserved within the dosage range of 500ppm to 1500ppm but it is most commonly used at a level of 1000ppm. In certain topical and oral pharmaceuticals, Protectol DA is used as an active ingredient. Use levels range from 0.06% for oral administration to 0.5% for skin disinfection.

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Aako BV
P.O. Box 205
3830 AE Leusden
The Netherlands
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