Dex-Panthenol Ph. Eur.

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Therapeutic use: Excipient

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CAS: 81-13-0

Panthenol is an active ingredient for sophisticated cosmetic skin care and hair care products. It improves the appearance of skin, hair and nails. D-Panthenol is the provitamin of D-Pantothenic acid (Vitamin B5). D-Pantothenic acid plays a key role in the human intermediary metabolism. It is a part of the Coenzym A. Deficiency of Vitamin B5 results in many dermatological disorder. Coenzym A is important for:

structure and function of living tissue
resistance of the mucous membrane
growth and pigmentation of hair

Role in the skin:

deep penetrating moisturizer
stimulates epithelisation
has wound healing effect
has an anti-inflammatory effect

Role in the hair:

long lasting moisturizer
prevents hair damage
thickens hair
improves luster and sheen

Role in nail care:

improves hydration
imparts flexibility

Only the D-Panthenol is the provitamin of D-Pantothenic acid (Vitamin B5), not the L-Panthenol. The human body converts D-Panthenol to Vitamin B5, which is D-Panthotenic acid. DL-Panthenol is a lit racemic mixture of D-Panthenol and L-Panthenol. Due to the fact that only D-Panthenol is converted to Vitamin B5 and not LPanthenol, the racemic DL-Panthenol has only half of the physiological activity of the D-Panthenol. These include stimulation of epithelisation, wound healing effect and anti-infl ammatory effect. But for all the none physiological activities like moisturizer effect, improvement of hair structure, giving luster and sheen to the hair D- and DL-Panthenol are equally active. The D-Panthenol USP and 50 P are also applied in the pharmaceutical industry. The main areas of pharmaceutical application are syrups, drops, ampoules, creams, gels and capsules. In liquid multi-vitamin and Vitamin B complex preparations D-Panthenol is nearly always preferred to the D-Pantothenates because it is usually considerably more stable at the pH values below 5 usually employed in these preparations.

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