Sodium Propyl p-Hydroxybenzoate.

Nipasol M Sodium is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries pharmaceuticals. Nipasol M Sodium is suitable to preserve both rinse- off and leave- on formulations.
Nipasol M Sodium is effective against bacteria, molds and yeast. The recommended use level of Nipasol M Sodium to preserve most product types is normally in the range of 0.1- 0.3 % based on the total weight of the finished product.
The Paraben esters have many advantages as preservatives, like broad spectrum antimicrobial activity, effective at low use concentrations, compatible with a wide range of cosmetic ingredients, colourless, odour-less, well documented toxicological and dermatological acceptability based on human experience (used in cosmetics, food and pharmaceuticals since 1930ies), p-Hydroxybenzoic Acid and a number of its esters occur naturally in a variety of plants and animals, stable and effective over a wide pH- range, etc.
The Sodium Parabens, like Nipasol M Sodium have several additional advantages:
- Nipasol M sodium is highly soluble in cold water for ease of addition.
- No heating stage required for incorporation, thus saving energy and plant occupancy.
- Increased antimicrobial activity at alkaline pH.

Nipasol M Sodium is designed for preservation of a wide range of cosmetics and toiletries. Nipasol M Sodium is suitable to preserve both rinse- off and leave- on formulations. Formulations which are prone to bacteria contamination an additional antibacterial preservative, like Nipaguard DMDMH might be nec-essary to add as Nipasol M Sodium provides a higher efficacy against fungi than against bacteria.

Nipasol M Sodium is highly soluble in water and so easily incorporated into cosmetic formulations. It is important to note that, whilst the aqueous solubil-ity in alkaline solution is high, if the pH of the formu-lated product is acidic the sodium salt reverts to the ester and the low solubility is regained.

pH stability
Nipasol M Sodium remains fully stable over a wide pH range from 3.0- 11.0. Aqueous solutions of Nipasol M Sodium are not long- term stable at alkaline pH.

Temperature stability
The recommended maximum handling temperature is 80°C.